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Catalytic Promiscuity of cGAS: A Facile Enzymatic Synthesis of 2′‐3′‐Linked Cyclic Dinucleotides
to δH 3.31 ppm and δC 49.0 ppm.
Cyclic GMP-8-NH2-AMP: 1H NMR (600 MHz, D2O/CD3OD): δ=8.08 (s,
1H; CH), 7.94 (s, 1H; CH), 6.17 (s, 1H; CH), 5.99 (d, J=8.2 Hz, 1H; CH), 5.60 (dt, 3JH,H=8.6 Hz, 4.3 Hz, 1H; [...] 14.3–16.3 min; cyclic GMP-8-Cl-AMP: 0–5 min: 0% B, 5– 25 min: 0 to 30% B, 25–27 min: 30 to 90% B, 27–35 min: 90% B, 35–37 min: 90 to 0% B, 37–47: 0% B; Fractions were taken:12.7– 14.1 min and 16.3–18.3 [...] (s, 1H; CH), 6.47 (m, 1H; CH), 5.96 (m, 1H; CH), 5.67 (dt, 3JH,H=8.2 Hz, 4.3 Hz, 1H; CH), 5.56 (m, 1H; CH), 5.12 (m, 1H; CH), 4.60 (d, J=4.3 Hz, 1H; CH), 4.57 (m, 1H; CH), 4.40 (m, 1H; CH), 4.25 (m, 2H; …
